Funding

EMONET is funded by UEFISCDI grant PN-III-P1-1.1-TE-2019-0502.

Team

EMONET’s core team

Bogdan Blidarescu, MS student
Irina Oane, MD, PhD
Cristian Donos, PhD (project leader)

Collaborators

  • University of Bucharest:

    Andrei Barborica, PhD
    Constantin Pistol, PhD student

  • Bucharest University Hospital:

    Ioana Mindruta, MD, PhD

Results

EMONET team members

Publications

  1. Oane, Irina; Barborica, Andrei; Chetan, Filip; Donos, Cristian; Maliia, Mihai Dragos; Arbune, Anca Adriana; Daneasa, Andrei; Pistol, Constantin; Nica, Adriana Elena; Bajenaru, Ovidiu Alexandru; Cingulate cortex function and multi-modal connectivity mapped using intracranial stimulation; NeuroImage; 220;117059;
  2. Woolnough, Oscar; Donos, Cristian; Rollo, Patrick S; Forseth, Kiefer J; Lakretz, Yair; Crone, Nathan E; Fischer-Baum, Simon; Dehaene, Stanislas; Tandon, Nitin; Spatiotemporal dynamics of orthographic and lexical processing in the ventral visual pathway; Nature Human Behaviour; 5; 3; 389-398; 2021
  3. Barborica, Andrei; Mindruta, Ioana; Sheybani, Laurent; Spinelli, Laurent; Oane, Irina; Pistol, Constantin; Donos, Cristian; López-Madrona, Victor J; Vulliemoz, Serge; Bénar, Christian-George; Extracting seizure onset from surface EEG with Independent Component Analysis: insights from simultaneous scalp and intracerebral EEG; NeuroImage: Clinical; 32; 102838; 2021
  4. Bratu, Flavius-Ionut; Oane, Irina; Barborica, Andrei; Donos, Cristian; Pistol, Constantin; Daneasa, Andrei; Lentoiu, Camelia; Mindruta, Ioana; Network of autoscopic hallucinations elicited by intracerebral stimulations of periventricular nodular heterotopia: An SEEG study; Cortex; 145; 285-294; 2021
  5. Snyder, Kathryn M; Forseth, Kiefer J; Donos, Cristian; Rollo, Patrick S; Fischer-Baum, Simon; Breier, Joshua; Tandon, Nitin; The critical role of the ventral temporal lobe in word retrieval;bioRxiv; 2021
  6. Woolnough, Oscar; Donos, Cristian; Curtis, Aidan; Rollo, Patrick S; Roccaforte, Zachary J; Dehaene, Stanislas; Fischer-Baum, Simon; Tandon, Nitin; A Spatiotemporal map of reading aloud; Journal of Neuroscience; 2022;
  7. Barborica, Andrei; Oane, Irina; Donos, Cristian; Daneasa, Andrei; Mihai, Felicia; Pistol, Constantin; Dabu, Aurelia; Roceanu, Adina; Mindruta, Ioana; Imaging the effective networks associated with cortical function through intracranial high‐frequency stimulation; Human brain mapping; 43; 5; 1657-1675; 2022
  8. Lentoiu, Camelia; Oane, Irina; Barborica, Andrei; Donos, Cristian; Pistol, Constantin; Daneasa, Andrei; Bratu, Flavius I; Mindruta, Ioana; Motor and emotional facial features in parietal lobe seizures: an ictal functional connectivity study using SEEG; Epileptic Disorders; 1; 1; 1-9; 2022
  9. Cristian Donos, Bogdan Blidarescu, Constantin Pistol, Irina Oane, Ioana Mindruta, Andrei Barborica; A comparison of uni- and multi-variate methods for identifying brain networks activated by cognitive tasks using intracranial EEG; Frontiers in Neuroscience 2022; – in review.

Conferences

2022:

  1. Cristian Donos, Bogdan Blidarescu, Irina Oane, Constantin Pistol, Ioana Mindruta, Andrei Barborica - „Search light analysis for intracranial EEG recordings”, FENS Forum, 9-13 July 2022, Paris, France
  2. Andrei Barborica, Ioana Mindruta, Christian Benar, Victor Lopez-Madrona, Irina Oane, Felicia Mihai, Cristian Donos, Constantin Pistol - „Intracranial Stimulations as Ground Truth for Testing Visibility of Deep High-Frequency EEG Sources - A Simultaneous Scalp-SEEG Study”, American Epilepsy Society, 2-6 December 2022, Nashville TN, USA
  3. Irina Oane, Andrei Barborica, Felicia Mihai, Andrei Daneasa Flavius Bratu, Camelia Lentoiu, Constantin Pistol, Cristian Donos, Ioana Mindruta - „Network of insular physiologic and epileptogenic signs and symptoms”, American Epilepsy Society, 2-6 December 2022, Nashville TN, USA
  4. Flavius Bratu, Andrei Barborica, Irina Oane, Camelia Lentoiu, Felicia Mihai, Cristian Donos, Constantin Pistol, Ioana Mindruta - „Gray matter heterotopias – is there something more than meets the eye on scalp EEG traces? - simultaneous scalp EEG-stereo-EEG study”, 32nd International Congress of Clinical Neurophysiology, 4-8 September 2022, Geneva , Switzerland

2021:

  1. Bogdan Blidarescu, Cristian Donos, Constatin Pistol, Irina Oane, Andrei Barborica, Ioana Mindruta - “The brain network of facial emotions”, Romanian Society of Electrodiagnostic Neurophysiology Summer School, 9-10 July 2021
  2. Irina Oane, Andrei Barborica, Cristian Donos, Constantin Pistol, Andre Daneasa, Camelia Lentoiu, Flavius Bratu, Ioana Mindruta –“ Crize reflexe si retelele neuronale implicate “, Romanian Society of Electrodiagnostic Neurophysiology Summer School, 9-10 July 2021
  3. Bogdan Blidarescu, Constantin Pistol, Irina Oane, Ioana Mindruta, Andrei Barborica, Cristian Donos – “A machine learning alternative to identifying contrasts during cognitive tasks”, Society for Neuroscience 2021, Online Conference, 8-11 November 2021
  4. Cristian Donos, Bogdan Blidarescu, Constantin Pistol, Irina Oane, Ioana Mindruta, Andrei Barborica – “Multivariate pattern analysis identifies brain networks in sparse intracranial EEG recordings”, Society for Neuroscience 2021, Online Conference, 8-11 November 2021
  5. Cristian Donos, Irina Oane, Ioana Mindruta, Flavius Bratu, Camelia Lentoiu, Felicia Mihai, Andrei Barborica - “Why do we perform intracranial stimulation studies during SEEG presurgical exploration? – the role of CCEP analysis” , The Romanian Society Against Epilepsy National Conference, 25-27 Noiembrie 2021
  6. Andrei Barborica, Ioana Mindruta, Christian G. Benar, Serge Vulliemoz, Irina Oane, Felicia Mihai, Cristian Donos, Constantin Pistol – “What Scalp Recordings Tell Us About Intracranial Stimulations? A Simultaneous Scalp-SEEG Study”, American Epilepsy Society 2021
  7. Ioana Mindruta, Irina Oane, Flavius Bratu, Camelia Lentoiu, Felicia Mihai, Cristian Donos, Andrei Barborica – “Insular-Cingulate Resting State and Symptom Related Connectivity Interplay in Patients with Drug-Resistant Epilepsy”, American Epilepsy Society 2021

2020:

  1. Ioana Mindruta, Irina Oane, Andrei Daneasa, Cristian Donos, Sergiu Stoica, Georgian Ciobotaru, Jean Ciurea, Andrei Barborica “Defining success in epilepsy surgery”, online National Conference of the Romanian League against Epilepsy, 4-7 November 2020
  2. Camelia Lentoiu, Irina Oane, Andrei Barborica, Cristian Donos, Andrei Daneasa, Flavius I. Bratu, Ioana Mindruta. Parietal lobe seizure: a combined scalp-intracranial electrode study online National Conference of the Romanian League against Epilepsy, 4-7 November 2020
  3. Ionuț-Flavius Bratu, Camelia Lențoiu, Tudor Cornel, Aura Dabu, Irina Oane, Andrei Dăneasa, Sergiu Stoica, Georgian Ciobotaru, Andrei Barborică, Ioana Mîndruță. Anterior, middle and posterior insular cortex – an archipelago to be discovered: a scalp EEG-SEEG study online National Conference of the Romanian League against Epilepsy, 4-7 November 2020
  4. Irina Oane, Ioana Mindruta “Epilepsy surgery in eloquent cortex – case presentation” 7th Tagliacozzo International Course on Drug Resistant Epilepsies - Virtual Event, 23-25 september 2020
  5. Ioana Mîndruta, Andrei Barborica, Cristian Donos, Mihai Mălîia, Irina Oane, Anca Arbune “Signal analysis method to delineate the seizure onset zone” MEL2020 online conference organised by the Hungarian Epilepsy League 29-30 october 2020

Objectives

1: To investigate the validity of two emotion network models: We will study the temporal dynamics of task-related activations in the cortical and subcortical structures described by the two models using intracranial recordings that provide excellent temporal resolution.

2: To provide an in-depth, multi-modal characterization of the emotion network involved in processing facial expressions:We will provide the first multi-modal characterization of the emotion network in terms of the functional (FC) and structural (SC) connectivity. FC will be inferred using task-related gamma activations, and the nonlinear correlation coefficient h2, while SC will be assessed using DWI.

Abstract

Emotional states are one of the main contributors to human behavior, and are heavily influenced by the physiological responses of the human body to internal and external stimuli. Ineffective emotion regulation has been linked to numerous clinical conditions, including depression. The high occurrence of such clinical conditions has a high economic and cultural impact on today’s society.

There are two state of the art models of the brain emotion network. LeDoux’s model builds on the idea that humans developed a survival mechanism for immediate threat detection that required fast responses to visual stimuli, with two routes (cortical and subcortical) involved in the process of threat detection. Pessoa’s model also describes cortical and subcortical routes, but with a higher emphasis on the cortical route, which includes parallel processing of the stimuli in frontal and parietal brain regions. However, these theoretical models are yet to be empirically validated by a data-driven approach.

Our objective is to study the emotion network using intracranial EEG data from patients undergoing presurgical evaluation for drug-resistant epilepsy, diffusion-weighted imaging (DWI), and two cognitive tasks consisting of images of faces with emotional content.